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Table 4 Differential changes of variables following placebo and calcitriol treatments in subjects with FF and Ff genotypes of the VDR FOKI polymorphism

From: The efficacy of calcitriol treatment in non-alcoholic fatty liver patients with different genotypes of vitamin D receptor FokI polymorphism

Variable FOKI FF genotype(n = 68) FOKI Ff genotype (n = 58) p-value
placebo Calcitriol placebo Calcitriol Group Genotype Interaction
weight, kg −0.16 ± 2.4 0.24 ± 1.8- − 1.0 ± 2.3 0.5 ± 3.8- 0.67 0.24 0.57
BMI, kg/m2 0.00 ± 0.75- −0.21 ± 1.0 − 0.36 ± 0.8 0.2 ± 1.3- 0.89 0.35 0.34
WC, cm −0.8 ± 1.8 0.12 ± 2.8 −0.8 ± 1.9 −0.3 ± 2.0 0.10 0.58 0.55
HC, cm 0.16 ± 3.4 0.8 ± 3.6- −0.6 ± 1.4 − 0.6 ± 3.0 0.37 0.58 0.39
FBS, mg/dl −2.0 ± 13.5 2.0 ± 19.3 1.3 ± 9.1 −4.6 ± 42.8 0.82 0.71 0.27
Insulin −0.05 ± 6.8 0.12 ± 6.4 0.2 ± 6.7 0.1 ± 4.6 0.97 0.90 0.91
Homa-IR −0.2 ± 0.7 0.1 ± 1.3 0.08 ± 0.9 − 0.2 ± 1.0 0.74 0.90 0.09
TC, mg/dl −4.5 ± 60.1 −7.8 ± 33.7 1.6 ± 46.1 −8.8 ± 47.4 0.43 0.86 0.68
TG.mg/dl −8.1 ± 95.1 −29.2 ± 99.8 5.3 ± 83.2 1.0 ± 82.0 0.46 0.20 0.62
HDL -C, mg/dl −2.2 ± 10.9 −3.1 ± 9.7 1.4 ± 8.8 −1.2 ± 11.0 0.34 0.14 0.66
LDL-C, mg/dl 7.5 ± 26.1 5.0 ± 21.3 7.4 ± 23.7 6.4 ± 27.4 0.71 0.89 0.87
AS, IU 0.08 ± 15.3 −4.9 ± 7.3 −1.2 ± 8.5 −2.4 ± 8.4 0.10 0.74 0.31
ALT, IU −12.6 ± 22.3 − 15.3 ± 19.9 −10.2 ± 17.4 −11.2 ± 12.2 0.58 0.34 0.80
GGT, IU 0.18 ± 28.9 −5.3 ± 13.5 −5.6 ± 15.6 7.6 ± 48.5 0.50 0.51 0.09
ALK, IU −26.3 ± 74.7 −23.0 ± 38.1 2.2 ± 54.5 −33.3 ± 42.8 0.11 0.36 0.05
Vitamin D −0.1 ± 6.4 2.1 ± 9.1 1.1 ± 6.4 0.73 ± 5.9 0.13 0.39 0.86
Hs-CRP,μg/ml 0.12 ± 3.2 0.0 ± 2.9 −0.38 ± 4.7 −1.3 ± 6.0 0.53 0.28 0.63
Leptin, ng/ml −6.3 ± 17.9 −2.6 ± 12.6 −6.6 ± 21.1 −6.2 ± 13.3 0.53 0.55 0.61
Adiponectin, μg/m −4.5 ± 12.2 −4.4 ± 14.2 0.05 ± 12.8 −1.8 ± 7.8 0.75 0.13 0.69
HSI −2.2 ± 3.8 3.1 ± 4.5- − 2.7 ± 4.9 −2.7 ± 4.1 0.56 0.92 0.54
APRI 0.0 ± 0.2 −0.04 ± 0.1 0.0 ± 0.1 −0.03 ± 0.1 0.20 0.95 0.73
  1. Values are expressed as the mean ± SD. BMI Body mass index, WC Waist circumference, HC Hip circumference, FBS Fasting blood glucose, Homa-IR Homeostatic Model Assessment for Insulin Resistance, HS index Hepatic steatosis index, APRI AST to Platelet Ratio Index, TC total cholesterol, TG Triglyceride, HDL-c High-density lipoproteins- cholesterol, LDL-c Low density lipoprotein- cholesterol, AST aspartate aminotransferase, ALT Alanine aminotransferase, GGT Gamma-glutamyl transferase, ALK Alkaline phosphatase, Hs-CRP High-sensitivity C-reactive protein
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BMC Pharmacology and Toxicology

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