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Table 2 Values of demographic and biochemical variables before and after calcitriol and placebo interventions

From: The efficacy of calcitriol treatment in non-alcoholic fatty liver patients with different genotypes of vitamin D receptor FokI polymorphism

Variable Baseline Week 16 P value
Placebo Calcitriol Plasebo Calcitriol Group Time Group * Time
Weight,kg 83 ± 11.7 83 ± 13.1 82 ± 12.5 83 ± 12.8 0.840 0.746 0.781
BMI, kg/m2 29.1 ± 3.9 29.1 ± 4.7 28.6 ± 4.2 28.8 ± 4.5 0.595 0.754 0.812
WC, cm 101 ± 10.9 100 ± 8.9 100 ± 11.9 100 ± 9.1 0.503 0.854 0.714
HC, cm 107 ± 7.6 106 ± 9.2 106 ± 8.6 106 ± 9.1 0.860 0.512 0.872
TC, mg/dl 188 ± 62.0 187 ± 46.5 187 ± 41.0 179 ± 41.8 0.441 0.827 0.783
TG.mg/dl 180 ± 80.9 194 ± 100.1 178 ± 92.6 177 ± 73.4 0.502 0.814 0.501
HDL-c, mg/dl 40.9 ± 9.3 38 ± 7.9 40.8 ± 11.9 36 ± 9.8 0.001 0.262 0.990
LDL-c, mg/dl 96 ± 25.9 94 ± 23.4 103 ± 22.3 99 ± 27.4 0.551 0.173 0.806
FBS, mg/dl 94 ± 24.0 98 ± 38.4 94 ± 19.9 97 ± 20.0 0.881 0.908 0.813
Insulin, μIU/ml 10.6 ± 5.6 9.2 ± 4.8 10.7 ± 5.7 9.3 ± 4.2 0.737 0.646 0.761
Homa-IR 2.1 ± 0.9 2.0 ± 0.9 2.0 ± 0.8 2.0 ± 0.9 0.546 0.449 0.879
Quicki 0.3 ± 0.03 0.3 ± 0.03 0.3 ± 0.03 0.3 ± 0.03 0.433 0.343 0.672
AST, IU 27 ± 12.6 27 ± 8.7 27 ± 14.5 23 ± 6.1 0.95 0.129 0.713
ALT, IU 47 ± 28.5 43 ± 16.1 35 ± 23.8 30 ± 11.4 0.209 0.000 0.650
GGT, IU 33.5 ± 12.5 35.8 ± 21.3 30.6 ± 21.1 35.9 ± 34 0.245 0.767 0.190
ALK, IU 198 ± 50.1 197 ± 54.9 188 ± 50.7 169 ± 47.3 0.023 0.004 0.030
HSI Index 41.5 ± 5.8 41.3 ± 5.7 38 ± 6.1 38.2 ± 6.0 0.390 0.006 0.647
APRI index 0.3 ± 0.1 0.3 ± 0.1 0.3 ± 0.0 0.2 ± 0.0 0.154 0.242 0.983
Hs-CRP, μg/ml 3.7 ± 3.5 4.5 ± 6.0 3.4 ± 4.2 3.9 ± 5.2 0.320 0.495 0.907
Leptin, ng/ml 17.5 ± 20 14.6 ± 13.9 11.3 ± 9.7 10.6 ± 12.1 0.798 0.001 0.655
Adiponectin, μg/ml 20.5 ± 11.3 21 ± 14.6 18.7 ± 9.7 17.5 ± 10.0 0.57 0.006 0.282
  1. Values are expressed as the mean ± SD. BMI Body mass index, WC Waist circumference, HC Hip circumference, FBS Fasting blood glucose, Homa-IR Homeostatic Model Assessment for Insulin Resistance, HS index Hepatic steatosis index, APRI AST to Platelet Ratio Index, TC total cholesterol, TG Triglyceride, HDL-c High-density lipoproteins- cholesterol, LDL-c Low density lipoprotein- cholesterol, AST aspartate aminotransferase, ALT Alanine aminotransferase, GGT Gamma-glutamyl transferase, ALK Alkaline phosphatase, Hs-CRP High-sensitivity C-reactive protein
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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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