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Indexs
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Control
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H-BH4
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L-BH4
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H-N
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L-N
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L-N&L-BH4
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L-N&H-BH4
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H-N&L-BH4
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H-N&H-BH4
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|---|
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(n = 6)
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(n = 6)
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(n = 6)
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(n = 6)
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(n = 6)
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(n = 6)
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(n = 6)
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(n = 6)
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(n = 6)
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|---|
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Body weight g
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249.8± 5.0
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251.2± 5.5
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248.6± 5.2
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251.1± 3.5
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248.6± 5.7
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257.1±5.9
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253.2±11.9
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253.3±3.8
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247.3± 2.8
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Systolic BP,mm Hg
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210.0±10.1
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193.4±19.4
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196.5±9.4
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185.2±9.7**
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190.1±23.8
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185.5±16.6*
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188.4±20.8*
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186.±16.0*
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185.1±11.5*
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Heart rate, bpm
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447±37
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448±12##
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436±34
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347±11*
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366±7
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361±5
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343±57
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332±10*#
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331±6*##
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Diastolic measures
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E`
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29.83±1.16
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34.66±1.03**##
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33.00±1.09**##
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48.00±0.89**##
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31.16±1.17*##
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37.83±1.16**##
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28.00±0.89*##
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33.00±1.09**##
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29.50±1.04##
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E/E′
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23.49±0.95
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15.25±0.36**
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19.65±0.63**##
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18.63±0.45**##
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20.45±1.40*##
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15.43±0.75**
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19.65±0.10**##
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17.38±0.77*##
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13.72±0.46##
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E′/A′
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0.77±0.03
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1.19±0.03**
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0.99±0.12**#
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1.21±0.06**
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1.07±0.05**
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1.21±0.09**
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1.03±0.07**
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1.10±0.03**##
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1.32±0.05##
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Invasive measure
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Heart rate
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399.1±34.2
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371.3±50.2
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398.4±38.6
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354.0±24.1*
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368.5±19.4
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364.8±41.3
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385.5±15.1
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349.1±39.8**
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353.9±33.2*
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Systolic function
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Max LVSP
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168.06±3.94
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144.8±7.67**
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131.81±6.09**
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124.81±8.2**
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139.35±4.3**
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162.37±9.06
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136.3±4.33**
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153.59±9.1*
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146.17±0.64*
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+dP/dtmax, mm Hg/s
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8338.20±366.75
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8268.8±277.50
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7257.63±73.54##
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7724.35±107.6##
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8279.39±246.2
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8228.84±76.82
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6732.±96*##
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5212±326**##
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4642±240**##
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Diastolic function
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LVEDP
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24.56±4.18
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14.55±1.82**
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16.2±1.21**
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15.95±1.50**#
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17.99±2.04**
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14.56±1.40**
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16.86±2.83**
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14.89±0.52**
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12.43±3.04##
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-dP/dtmin,mmHg/s
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-6992±123
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-6780±284##
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-6568±149##
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-6599±287##
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-6610±195##
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-7753±223*
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-6598±134##
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-6854±224*##
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-7787±489*##
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-dP/dtmin/lvsp
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-41.65±1.4
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-46.98±4.32*
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-49.91±2.72**
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-53.02±4.0**
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-47.4±0.83*
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-47.9±3.98*
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-48.4±2.48**
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-40.28±3.44
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-55.62±1.60
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tau
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38.28±2.48
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25.58±0.63**
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23.67±0.63**
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27.84±2.05**
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29.38±2.98**##
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25.42±1.38**
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22.53±2.65**##
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25.60±0.48**
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20.55±4.12*##
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- Notes: Values are means ± SD. WKY, Wistar-Kyoto rats; SHR, spontaneously hypertensive rat; BP, blood pressure; E = peak early diastolic LV filling velocity; A = peak late diastolic LV filling velocity; E/A = peak E and A velocity ratio; E’and A’, maximal velocity of mitral annulus during early and late diastole; LVEDd, LV end-diastolic dimension; LVSP, LV systolic pressure; tau, time constant of isovolumic LV relaxation.*represents compared with control, P < 0.05,**represents P < 0.01; # represents compared with group L-N&L-BH4, P < 0.05, ## represents P < 0.01
