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Indexs
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WKY(n = 6)
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SHR(n = 6)
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P
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|---|
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Body weight, g
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251.06±12.70
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246.78±5.32
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0.78
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Noninvasive measure
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Systolic blood pressure, mm Hg
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121.10±6.56
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207.66±14.12
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0.001
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Heart rate, bpm
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370.66±20.04
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409.66±47.19
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0.030
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Diastolic measures
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Peak early diastolic LV filling velocity
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708.2±6.52
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702±11.39
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0.318
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Peak E and A velocity ratio
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2.03±0.12
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1.55±0.08
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0.014
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E/E’
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20.25±0.62
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22.67±0.92
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0.001
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E’/ A’
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1.58±0.23
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0.86±0.02
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<0.001
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Systolic measures
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Fraction shortening, %
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40.65±0.24
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41.65±0.93
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NS
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Ejection fraction, %
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74.63±0.38
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75.86±1.03
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NS
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LV dimensions
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LV posterior wall thickness, mm
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1.26±0.08
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1.37±0.02
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0.014
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LV end-diastolic dimension, mm
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6.03±0.03
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6.04±0.05
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NS
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Invasive measure
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Heart rate
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342.67±47.11
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382.56± 46.05
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0.025
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Systolic function
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Max LV systolic pressure
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101.55 ±4.64
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146.60±11.29
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0.001
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dP/dtmax, mm Hg/s
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6344.01±1744.84
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7975.70±1434.87
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0.09
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Diastolic function
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LV end-diastolic pressure
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11.92± 5.94
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51.64±14.96
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0.001
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dP/dtmin,mm Hg/s
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-4258.06±375.55
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-6299.40±1192.38
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0.001
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dP/dtmin/LVSP
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-49.17±6.60
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-38.19±5.62
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0.004
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Time constant of isovolumic LV relaxation
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18.51±3.35
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25.9±3.38
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0.001
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- Notes: Values are mean ± SD. NS means the difference was not statistically significant. A: Peak late diastolic LV filling velocity; E: Peak early diastolic LV filling velocity; E’and A’: Maximal velocity of mitral annulus during early and late diastole, LV: Left ventricle; LVSP: LV systolic pressure; SHRs: Spontaneously hypertensive rats, WKY: Wistar-Kyoto rats
