Oral intermittent vitamin D substitution: influence of pharmaceutical form and dosage frequency on medication adherence: a randomized clinical trial

Table 3 Listing of all reported unexpected events after 3 or 6 months of cumulative weekly or monthly oral treatment with 800 IU cholecalciferol/day (translated from Swiss German)

Preparation	Unexpected event
oily drops	fatigue, but also occurred before
alcoholic drops	possible fatigue, unclear whether there is a connection
oily drops	uncharacteristic abdominal pain
oily drops	shingles: under Vit D considerably less frequent
oily drops	less tired than usual
alcoholic drops	generally feels better under vitamin D, is better off in the morning
oily drops	foot swelling left 1 week ago - now better
oily drops	nervous, palpitations
alcoholic drops	weight loss 7 kg in 2 months (patient report not validated)
alcoholic drops	feeling, I let more water than usual (suspected diuretic effect)
alcoholic drops	heat feeling, feverish, sleep problems
alcoholic drops	had once cramp in the leg
oily drops	less pain in the hand
alcoholic drops	localized itching
alcoholic drops	a little gas (flatulence)
oily drops	possibly more diarrhea (developed over time)
oily drops	at the first 3 doses some nausea after ingestion, spontaneously gone
capsules	approx. 10 days after the 1st ingestion night sweat outbreak (one-time)
oily drops	unique feeling of palpitations

ISSN: 2050-6511