Table 1 Physiological and biological input parameters for PK-Sim Simulation
| Parameters/Properties | Values used | Reference values | References | |
|---|---|---|---|---|
| Physicochemical | Lipophilicity (Log P) | -1.22 | -1.22 | [36] |
| Plasma protein binding | Does not bind | [37] | ||
| Molecular weight | 405.48g/mol | [38] | ||
| Pka | 2.5 | 2.5 (at pH 7) | [36] | |
| Solubility (mg/L) at reference pH | 97000 | 97000 | [39]. | |
| Biological | Renal clearance | 0.56 ml/min/kg |
47±8.3ml/min 2.82±0.0083L/h | [40] |
| Metabolism | - | No metabolism | [30] | |
| Elimination | Renal route | Renal route | [30] | |