Clinical efficacy and safety in patients treated with teicoplanin with a target trough concentration of 20 μg/mL using a regimen of 12 mg/kg for five doses within the initial 3 days

Table 1 Teicoplanin dosing regimen according to renal function

Conventional high loading dose regimen						Enhanced high loading dose regimen
eGFR (ml/min /1.73 m²)	The total dose for the initial 3 days				Maintenance dose after day 3	eGFR (ml/min /1.73 m²)	The total dose for the initial 3 day				Maintenance dose after day 3
eGFR (ml/min /1.73 m²)	1st day	2nd day	3rd day	Total	Maintenance dose after day 3	eGFR (ml/min /1.73 m²)	1st day	2nd day	3rd day	Total	Maintenance dose after day 3
≥60	10 mg/kg twice daily	10 mg/kg twice daily	10 mg/kg once daily	50 mg/kg	6.7 mg/kg once daily	≥60	12 mg/kg twice daily	12 mg/kg twice daily	12 mg/kg once daily	60 mg/kg	6.7 mg/kg once daily
40–60	10 mg/kg twice daily	10 mg/kg once daily	10 mg/kg once daily	40 mg/kg	3.3 mg/kg once daily	30–60	12 mg/kg twice daily	12 mg/kg once daily	12 mg/kg once daily	48 mg/kg	5.0 mg/kg once daily
< 40	10 mg/kg twice daily	6.7 mg/kg once daily	6.7 mg/kg once daily	33.4 mg/kg	5.0 mg/kg every 2 days	< 30	12 mg/kg twice daily	12 mg/kg once daily	6.7 mg/kg once daily	42.7 mg/kg	6.7 mg/kg every 2 days

ISSN: 2050-6511