Table 3 Significant Risk factors determining odds of being acute vs. chronic Methotrexate toxicity (n = 27)
From: Acute versus chronic methotrexate poisoning; a cross-sectional study
| Characteristics | Acute (n = 13) | Chronic (n = 14) | p value | OR (95%CI) |
|---|---|---|---|---|
| RA Background disease n(%) | 3 (23.1) | 10 (76.9) | 0.021 | 8.3 (1.4, 47.2) |
| MTX oral formulation | 13 (61.9) | 8 (38.1) | 0.016 | 1.8 (1.1, 2.8) |
| MTX injection formulation | 0 | 5 (100) | 0.041 | 1.6 (1.1, 2.3) |
| Suicide Attempt n(%) | 10 (100) | 0 | > 0.001 | 0.23 (0.07, 0.62) |
| Error in time of prescription drug n(%) | 0 | 5 (100) | 0.041 | 1.6 (1.1, 2.3) |
| Skin lesions n(%) | 0 | 6 (100) | 0.016 | 1.7 [1.1, 2.7) |
| Oral ulcerations n(%) | 0 | 13 (100) | > 0.001 | 14 (2.1, 92.5) |
| Leukopenia n(%) | 1 (7.7) | 12 (92.3) | > 0.001 | 72 (5.7, 904.1) |
| Thrombocytopenia n(%) | 1 (7.7) | 14 (100) | > 0.001 | 15 (2.3, 99.6) |
| Anemia n(%) | 9 (39.1) | 14 (60.9) | 0.041 | 0.69 (0.48, 0.99) |